We seek a Senior Scientist to lead our Structural Biology group who will be responsible for crystallization, structure solution and modeling for the engineering of protein and antibody therapeutics.

Responsibilities:

  • Produce protein fractions for crystallization and characterize interactions by SPR
  • Utilize high throughput screening for the identification and optimization of crystallization conditions and collect diffraction data
  • Solve crystal structures and use modeling software to guide the engineering of therapeutics
  • Work with external x-ray sources, CROs, collaborators and partners to transfer molecules, structural data and protocols, into, or out of, Akriveia, as appropriate
  • Identify and integrate technologies that improve or expand the ability to crystalize and model proteins by working with teammates, collaborators, vendors, and staying abreast of the literature
  • Enter all data into laboratory notebooks and databases on a daily basis and ensure staff members do so, approve weekly progress reports from staff, and generate weekly summary reports for management
  • Regular participation and presentation of data and analyses at Project Team and department meetings
  • Provide proper training of staff, and continue to explore opportunities to expand their responsibilities and capabilities

Qualifications:

  • Ph.D., post-doctoral experience and +3 years in the field of protein crystallography and modeling or other relevant fields; ideally, with 2+ years’ experience working in a biotechnology or pharmaceutical company
  • Technical experience with all aspects of crystalizing proteins, including, protein expression, purification, and characterization (e.g. SEC, PAGE, SPR), high throughput crystallization and solving structures
  • Ability to run analyze complex computations and simulations at the molecular level such as, simulations of the structure and energetics of molecular systems
  • Deep experience with x-ray crystallography software and modelling packages, and ideally be able to augment modelling software, including porting to different computational environments
  • Experience managing staff is a plus
  • A track record of innovation and scientific rigor, strong problem solving and troubleshooting skills, and ability to contribute constructively to discussions
  • Goal oriented, organized, capable of prioritizing and working on multiple projects, and able to execute to timelines that meet company goals
  • Work well in a cross functional team environment, both independently as well as be willing to help others
  • Excellent verbal and written communication skills
  • Driven by a desire to create the next generation of immunotherapy based cancer therapeutics and the vision to offer cancer patients efficacious and tolerable new therapies that extend and improve their lives

We offer:

  • The opportunity to work in an innovation driven, exciting biotechnology company doing ground-breaking work in the field of immuno-oncology
  • The opportunity to work within and have a significant impact on a highly motivated team of like-minded people
  • Competitive compensation package including a base salary, annual bonus potential, stock options, 401k, healthcare benefits and paid time-off
  • This is a full-time position in the Cambridge, MA area

To apply for this position, please complete the following:

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