We seek a Senior Scientist for our Protein Biochemistry team to identify and validate protease substrates and tumor-associated proteases.

Responsibilities:

  • Design, create, quality control and screening of phage, yeast and/or mammalian cells libraries and validate hits
  • Develop and qualify assays for assessing enzyme activity in buffer, blood and tissues
  • Work with CROs, collaborators and partners to transfer sequences, molecules, data and protocols into, or out of, Akriveia, as appropriate
  • Identify and integrate technologies that improve or expand the ability to understand and utilize proteases and their substrates by working with teammates, collaborators, vendors, and staying abreast of the literature
  • Enter all data into laboratory notebooks and databases on a daily basis and ensure staff members do so, approve weekly progress reports from staff, and generate weekly summary reports for management review
  • Regular participation and presentation of data and analyses at Project Team and department meetings
  • Provide proper training of staff, and continue to explore opportunities to expand their responsibilities and capabilities

Qualifications:

  • Ph.D., post-doctoral experience and +3 years in the protease field or other relevant field; ideally, with 2+ years’ experience working in a biotechnology or pharmaceutical company
  • Technical experience with enzyme assays, DNA cloning, and library design, construction and screening
  • Experience with mammalian expression or protein purification is desirable
  • Experience managing staff is a plus
  • A track record of innovation and scientific rigor, strong problem solving and troubleshooting skills, and ability to contribute constructively to discussions
  • Goal oriented, organized, capable of prioritizing and working on multiple projects, and able to execute to timelines that meet company goals
  • Work well in a cross functional team environment, both independently as well as be willing to help others
  • Excellent verbal and written communication skills
  • Driven by a desire to create the next generation of immunotherapy based cancer therapeutics and the vision to offer cancer patients efficacious and tolerable new therapies that extend and improve their lives

We offer:

  • The opportunity to work in an innovation driven, exciting biotechnology company doing ground-breaking work in the field of immuno-oncology
  • The opportunity to work within and have a significant impact on a highly motivated team of like-minded people
  • Competitive compensation package including a base salary, annual bonus potential, stock options, 401k, healthcare benefits and paid time-off
  • This is a full-time position in the Cambridge, MA area

To apply for this position, please complete the following:

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